Online Catalog     Shopping Cart

Venoms
Discovery
Spider
Scorpion
Centipede
Toxin Index
Custom

 

Live Spiders

 

Educational
Spiders
Kits

 

Feeder Insect
Flies

 

Custom Services
Bioassay
Embryology
Silk
Tissues
Inquire

 

Contact
Inquiries
Suggestions

 

Wanted

 

Try our new Online Shop

This site is being revised and updated. Expect broken links and empty pages for next few days and contact us by phone or email if you cannot find what you are looking for.

graschil_2b.gif (26169 bytes)Grammostola rosae (=spatula) is a common Chilean tarantula which has become popular in the pet trade due to its attractive appearance and docile behavior. The spiders which Spider Pharm uses were collected by anonymous collector(s) in Chile and shipped through importers into the United States. Thus we do not locality data for these spiders as we do for species which we collected ourselves.

So far, research has concentrated peptide calcium and potassium channel antagonists from Grammostola spatulata venom that have useful selectivities. Recently, a novel antagonist of stretch-activated ion channels has also been characterized from the venom.

A toxin from this venom has also been proposed as a substitute for morphine: Zeneca Unveils Money Spider.

Our spiders were collected by anonymous collector(s) in Chile and shipped to importers in the United States, from whom we purchased the spiders. We do not have locality data as we do for our other species. Also, the taxonomy of these spiders has been fluctuating. For a time, some experts attempted to transfer this species to Phrixotrichus and you may find a paper to two on the venom of Phrixotrichus spatulata, which is the same spider.  As of this writing the experts appear to have reversed themselves and have returned this to Grammostola but are now using the species name G. rosea.

Characterized Toxins

  • Omega-grammotoxin SIA is a fairly non-selective voltage sensitive calcium channel antagonist, blocking mammalian N- and P-type calcium channels, but not the L-type.
  • GsMTx-4 blocks cationic stretch-activated ion channels in rat astrocytes. According to Suchyna et al. (2000) [PubMed] this is the "first [of many] reagent for mechanosensitive ion channels".
  • Hanatoxins are the first known peptide inhibitors of Kv2.1 voltage-activated potassium channels. However, the selectivity for this type is not absolute. They are also active against at least one shal-type.
  • Phrixotoxins, from the closely related Phrixotrichus auratus, specifically block Kv4.3 and Kv4.2 channels (Diochot, et. al. 1999 [medline])

Price List Medline References


 

Spider Pharm Inc * PO Box 1090 * Yarnell, AZ 85362
Phone: 1-928-427-6589
Fax: 928-441-1727
Webmaster, Inquires & Comments